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How it Works

VIRALEZE™ targets the area in the nasal cavity where respiratory viruses that cause colds, flu and more severe respiratory illness, such as COVID-19, first attach and start to multiply.

The nasal cavity is the primary site where SARS-CoV-2 (COVID-19) becomes established, before spreading to the lungs.^

VIRALEZE™ contains astodrimer sodium (SPL7013) which is antiviral and has been shown in laboratory studies to inactivate viruses, adding a further physical barrier to respiratory viruses.

^Hou, Y.J., et al. 2020. SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract. Cell 182(2), 429-446.e14. https://doi.org/10.1016/j.cell.2020.05.042
Paull, J.R.A. et al. Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro (2021). Antiviral Research: https://doi.org/10.1016/j.antiviral.2021.105089.

Astodrimer sodium (SPL7013) acts by blocking the interaction between the SARS-CoV-2 viral “spikes” and the human cells the virus is seeking to infect.

“Spike” proteins on the surface of these (SARS-CoV-2) viruses that come into contact with VIRALEZE™ are trapped by astodrimer sodium. This interaction is “virucidal” – the virus is irreversibly blocked and can no longer infect cells.

This mechanism provides a physical barrier to respiratory viruses in the nasal cavity. The “blocked” viruses are then cleared naturally through the nasal mucus.

Paull, J.R.A. et al. Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro (2021). Antiviral Research: https://doi.org/10.1016/j.antiviral.2021.105089.

Antiviral activity for astodrimer sodium (SPL7013) proven in laboratory studies.

Astodrimer sodium has demonstrated antiviral activity against a broad spectrum of respiratory viruses in laboratory studies including:

  • SARS-CoV-2 (the coronavirus that causes COVID-19)
  • MERS-CoV (the coronavirus that causes MERS)
  • SARS-CoV (the coronavirus that causes SARS)
  • H1N1 (the influenza virus that caused Swine Flu)
  • H3N2 (the influenza virus that caused Avian Flu)
  • RSV (respiratory syncytial virus)

Astodrimer sodium (SPL7013) has been shown to be virucidal, inactivating >99.9% of SARS-CoV-2 within one minute.

† Paull, J.R.A. et al. Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro (2021). Antiviral Research: https://doi.org/10.1016/j.antiviral.2021.105089.

Both pre- and post-infection assays show significant antiviral activity meaning that VIRALEZE™ could be used before or after exposure to virus.

Dose-response analysis of SARS-CoV-2 (2019-nCoV/USA-WA1/2020) antiviral activity of astodrimer sodium in Vero E6 cells as measured by infectious virus release. Astodrimer sodium was added to cell cultures 1 hour prior to or 1 hour post-infection.

Proven antiviral activity for astodrimer sodium (SPL7013)

Extensive data on the antiviral and virucidal activity of astodrimer sodium (SPL7013) against SARS-CoV-2 has been generated and is now published in the highly regarded, peer reviewed scientific journal, Antiviral Research.

The data confirms that astodrimer sodium (SPL7013) inhibits infection of host cells by SARS-CoV-2 when it is applied to the cells either before or after exposure to the virus (see Figure 1 below).

The selectivity of SPL7013 for SARS-CoV-2 in these assays was very high (selectivity index up to ~2200), indicating potent antiviral efficacy compared with minimal cellular toxicity. The selectivity index is a measure of therapeutic window.

In vitro testing at the prestigious Scripps Research Institute demonstrated the virucidal activity of astodrimer sodium (SPL7013) inactivating >99.9% of SARS-CoV-2, within one minute1. The virucidal effect was seen within one minute of exposure. The selectivity, or therapeutic index2 of astodrimer sodium (SPL7013) for SARS-CoV-2 is higher than reported for other known antiviral compounds3.

Testing of astodrimer sodium was conducted at The Scripps Research Institute and 360biolabs.
1 Paull, J.R.A. et al. Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro (2021). Antiviral Research: https://doi.org/10.1016/j.antiviral.2021.105089.
2 Selectivity index is a ratio of antiviral activity to cellular toxicity. The higher the selectivity index, the theoretically safer and more effective a compound would be in humans.
3 Pizzorno, A., et al., 2020. In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2. Antiviral Res. 181, 104878.  https://doi.org/10.1016/j.antiviral.2020.104878

Virucidal Assay: Virucidal efficacy of astodrimer sodium (SPL7013) against SARS-CoV-2 (2019-nCoV/USA-WA1/2020) measured by a reduction in mean infectious virus compared with virus control (virus without astodrimer sodium) in Vero E6 cells.

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