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How it Works
VIRALEZE™ acts locally in the nasal cavity where respiratory viruses that cause colds, flu, and more severe respiratory illness, first attach and start to multiply.
Astodrimer sodium in VIRALEZE™ is not absorbed into the bloodstream.
The nasal cavity is the primary site where respiratory viruses become established, before spreading to the lungs.
Mucus is naturally produced in the nose and its role is to trap foreign particles (e.g., dust or viruses) and reduce the chance of them infecting cells in the nasal cavity and entering the lungs.
The mucoadhesive formula of VIRALEZE™ provides a physical moisture barrier in your nose that hydrates the nasal mucosa for protection against mucosal drying and damage, thereby supporting your body’s natural defenses against viruses.
VIRALEZE™ also contains astodrimer sodium (SPL7013), which is antiviral and has been shown in laboratory studies to physically trap and block, and thereby inactivate, respiratory viruses^, providing a further physical barrier to respiratory viruses.
^ Paull, J.R.A. et al. Antiviral Res, 2021, 191, 105089
Paull, J.R.A. et al. Viruses, 2021, 13(8), 1656
Astodrimer sodium (SPL7013) acts by physically blocking the interaction between the respiratory viruses and the human cells the virus is seeking to infect.
Viruses that come into contact with VIRALEZE™ are trapped by astodrimer sodium in the formulation. This physical interaction is irreversible, and the blocked virus can no longer infect cells.
This mechanism provides a physical barrier to respiratory viruses in the nasal cavity. The trapped and blocked viruses are eliminated naturally through the nasal mucus.
^ Paull, J.R.A. et al. Antiviral Res, 2021, 191, 105089
Paull, J.R.A. et al. Viruses, 2021, 13(8), 1656
Broad-spectrum virus trapping and blocking effect of astodrimer sodium (SPL7013) demonstrated in multiple scientific studies^.
Performance of astodrimer sodium (SPL7013) against cold/respiratory virus vs. iota-carrageenan
The assay comparing astodrimer sodium (SPL7013) and iota-carrageenan (Sigma-Aldrich, MO, USA) against this cold/respiratory virus was conducted in Vero E6-hACE2-TMPRSS2 cells, according to standard virological methods, such as those described in Paull JRA et al., Antivir Res, 2021, 191, 105089.
